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KMID : 0941820110210010022
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Korean Journal of Clinical Pharmacy
2011 Volume.21 No. 1 p.22 ~ p.29
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Analysis of Gender Differences in Physician’s Desk Reference
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Heo Jung-Sun
Kim Kyung-Hee
Yoon In-Kyung
Kim Hyun-Ju
Kim You-Jin
Choi Jong-Min
Lee Byung-Koo
Lee Hwa-Jeong
Gwak Hye-Sun
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Abstract
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Purpose:This study aims to investigate how gender-based differences are actually reflected on drug approval.
Methods:Data on gender-based differences of drugs were analyzed by searching PDR (Physician’s Desk Reference) with the keyword, “GENDER”.
Results:There were descriptions related to gender in product directions of 361 drugs in 2009 PDR, out of which 63 items actually showed gender-related differences. Drug categories showing comparatively high gender-based differences were nervous system, cardiovascular system, and alimentary tract and metabolism. Pharmacokinetic differences between genders were observed most frequently; compared to men, 32 drugs showed higher absorption while 18 drugs revealed lower clearance in women. There were 2 drugs which gender should be considered before prescribing, and 5 drugs which showed different severity of adverse effects according to gender.
Conclusions :It is necessary to establish domestic policies for drug approval and use which reflects gender-based differences through sufficient researches.
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KEYWORD
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Gender-loased chfterences, Physician’s Desk Reference, Drug approval
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